Bisphenol A was investigated in the 1930s during the search for synthetic estrogens. Epoxy groups located at both ends of the molecule can undergo reactions of ring-opening, cross-linking and solidity with amines, anhydrides, and other curing agents of epoxy resins. Bisphenol A-type epoxy resin is bisphenol A and epichlorohydrin under the action of sodium hydroxide condensation derived. Bisphenol-F can further link generating tri- and tetra-and higher phenol oligomers. Toxicol Appl Pharmacol. MATERIAL SAFETY DATA SHEET West System Inc. MSDS #105-13a Last Revised: 26APR13 1. PBE can be used as a reinforcing polymer on nanotubes and nanoparticles which can be useful in electronics, optical and aerospace based applications. In fact, the Federal Trade Commission has specifically cautioned that free-of claims may deceive consumers by falsely suggesting that the marketer has improved the product by removing the substance.. The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice. Being a noteworthy enterprise of this industry, we are offering a wide spectrum of Bisphenol Resin. [28][29][30] Subsequent work found that it bound to estrogen receptors tens of thousands of times more weakly than estradiol, the major natural female sex hormone. Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats. Cured epoxy resins are inert materials used as protective liners in metal cans to maintain the quality of canned foods and beverages, and have achieved wide acceptance for use as protective coatings because of their exceptional combination of toughness, adhesion, formability, and chemical resistance. Chemical Formula . It belongs to the phenol class of aromatic organic compounds. By varying the relationship between bisphenol A and epichlorohydrin, various molecular weights are obtained for the completed epoxy resin. Usage: Industrial. It is commonly used in curing fast-drying epoxy resin adhesives. The CLARITY Study, the largest study ever done on BPA and conducted by FDA experts, confirms that BPA is safe, and supports the agencys one word answer to the question: Is BPA safe?: Yes. As can be seen from above, the product is bisphenol A diglycidyl ether when there is sufficient epichlorohydrin and enough sodium hydroxide as the catalyst. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. This compound is synthesized by the condensation of acetone with phenol. FDAs current perspective, based on its most recent safety assessment, is that BPA is safe at the current levels occurring in foods. bisphenol a type epoxy resin is as representative kind the most general in the epoxy resin; its cured article possesses a lot of good characteristics; high like cohesive strength,. Liquid Epoxy Resins Show entries [28] BPA was never used as a drug. Questions & Answers on Bisphenol A Use in Food Contact Applications, Bisphenol A Overview & Response to Petitions, European Food Safety Authority Information on Bisphenol A. The study included an in utero phase, direct dosing to pups to mimic bottle feeding in neonates, and employed a dose range covering the low doses where effects have been previously reported in some animal studies, as well as higher doses where estrogenic effects have been measured in guideline oral studies. 2013 Jul 1;270(1):45-59. . [34] These are not always removed and are known impurities in commercial samples of BPA. It belongs to the phenol class of aromatic organic compounds. [4] The studies were evaluated for their relevance for regulatory hazard and/or risk assessment. Bisphenol A is an organic synthetic compound used in formulating plastics and epoxy resin. Free of claims are used to indicate that a product does not contain a certain material, such as BPA, but they can sometimes be misleading. Brand Names: Not applicable . 2011 Dec 15;207(3):298-305. f) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. Because of its extreme durability and strength, polycarbonate plastic is particularly useful for making component parts that need to be thin and light, but strong. The FDAs National Center for Toxicological Research is continuing with an additional study: Rodent chronic toxicity study, which is currently underway. [3]NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A, NIH Publication No. Comparison of life-stage-dependent internal dosimetry for bisphenol a, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. Singapore 069535, 6,6-Dimethyl-2-methylenebicyclo[3.1.1]heptane, BPA. Epoxy is the family of basic components or cured end products of epoxy resins.Epoxy resins, also known as polyepoxides, are a class of reactive prepolymers and polymers which contain epoxide groups. [65][24], As a result of the presence of BPA in plastics and other commonplace materials, most people are frequently exposed to trace levels of BPA. 25085-99-8) Suppliers Limit companies to: Worldwide USA China India EMAIL INQUIRY to 13 suppliers BOC Sciences | Address: Ramsey Road, Shirley, New York 11967, USA https://www.bocsci.com | Send Inquiry | Phone: +1- (631)-485-4226 BOC Sciences is a brand of BOCSCI Inc. The consensus of major government agencies around the world is that BPA is safe as used in food-contact applications. Its current uses are as a primary monomer in polycarbonate plastic and epoxy resins. Due to interest in the exposure to bisphenol A in the community1 and the workplace, OSHA developed a validated method to collect and analyze bisphenol A and diglycidyl ether of bisphenol A. Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics. Reports indicate that it is a minor skin irritant as well, although less so than phenol. The oligomers may vary in molecular weight from 340 and higher. BPA can also be found in breast milk. Bisphenol A (BPA, 80-05-7) is an organic compound used predominantly in the production of products made of polycarbonate plastic and epoxy resins that line food and beverage cans. 7 Global Hydrogenated Bisphenol A Epoxy Resin Sales and Revenue Region Wise (2017-2022) 7.1 Global Sales and Market Share, Region Wise (2017-2022) 7.2 Global Revenue (Revenue) and Market Share . In addition to receptor binding, the compound has been found to affect Leydig cell steroidogenesis, including affecting 17-hydroxylase/17,20 lyase and aromatase expression and interfering with LH receptor-ligand binding. [7] As the only by-product is water, it may be considered an industrial example of green chemistry. Theres a potential for harm or injury in nearly every activity we engage in whether its when we cross a street, ride in an automobile, or play in a baseball game. 2012 May-Jun;34(3):331-7. l) Patterson TA, Twaddle NC, Roegge CS, Callicott RJ, Fisher JW, Doerge DR. Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys. Compounds without a Phenanthrene Nucleus", "Bio-Based Aromatic Epoxy Monomers for Thermoset Materials", "European Union Summary Risk Assessment Report - Bis (2-ethylhexyl) Phthalate (DEHP)", "Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes", "Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004", "The state of bisphenol research in the lesser developed countries of the EU: a mini-review", "An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment", "Bisphenol A and baby bottles: challenges and perspectives", "Consolidated federal laws of canada, Canada Consumer Product Safety Act", "MSC unanimously agrees that Bisphenol A is an endocrine disruptor - All news - ECHA", "EU court confirms BPA as substance of 'very high concern', "Estrogen biology: new insights into GPER function and clinical opportunities", "Global Assessment of Bisphenol A in the Environment: Review and Analysis of Its Occurrence and Bioaccumulation", "A critical analysis of the biological impacts of plasticizers on wildlife", Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione), DHEA (androstenolone, prasterone; 5-DHEA), 7-Methyl-19-norandrostenedione (MENT dione, trestione), 11-Methyl-19-nortestosterone dodecylcarbonate, Normethandrone (methylestrenolone, normethisterone), Oxabolone cipionate (oxabolone cypionate), Methylclostebol (chloromethyltestosterone), Andarine (acetamidoxolutamide, androxolutamide, GTx-007, S-4), Enobosarm (ostarine, MK-2866, GTx-024, S-22), 3-Methyl-19-methyleneandrosta-3,5-dien-17-ol, 10,17-Dihydroxyestra-1,4-dien-3-one (DHED), 16,17-Epiestriol (16-hydroxy-17-estradiol), 17-Epiestriol (16-hydroxy-17-estradiol), Epiestriol (16-epiestriol, 16-hydroxy-17-estradiol), Fosfestrol (diethylstilbestrol diphosphate), Furostilbestrol (diethylstilbestrol difuroate), Triphenylmethylethylene (triphenylpropene), https://en.wikipedia.org/w/index.php?title=Bisphenol_A&oldid=1134371642, Short description is different from Wikidata, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, Polycyanurates can be produced from BPA by way of its di-, Bisphenol-A formaldehyde resins are a subset of, BPA is used as an antioxidant in several fields, particularly in, Several drug candidates have also been developed from bisphenol A, including, Reprinted in condensed form in: A. Dianin (1892), This page was last edited on 18 January 2023, at 10:18. Background. You may have heard claims that BPA exposure causes health effects in people. BPA is a structural component in polycarbonate beverage bottles. In the United States, FDA is the agency charged with this review for food contact applications. [98] Despite its short half-life and non-bioaccumulating character, the continuous release of BPA into the environment causes continuous exposure to both plant[104] and animal life. Usage/Application: Polycarbonate , Epoxy resin, Thermal paper. Toxicol Appl Pharmacol. Polym Adv Technol 2009; 20: 194-208. . . The results of the independent evaluations were released in April 2010, as FDA made the CFSAN report and other relevant information available for public comment. At last,Bisphenol A epoxy resin() safety, risk, hazard and . Before sharing sensitive information, make sure you're on a federal government site. This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. Find out about the exciting discoveries being made by NIEHS and NIEHS-supported researchers that are helping to improve health and save lives. Research studies pursued by FDAs National Center for Toxicological Research have [6]: Found evidence in rodent studies that the level of the active form of BPA passed from expectant mothers to their unborn offspring, following oral exposure, was so low it could not be measured. Bisphenol A (BPA) is a diphenylmethane derivative, commonly used in the production of polycarbonate plastics, epoxy resins, and various other plastic-based consumer products. The reaction process is as follows: Based on FDAs ongoing safety review of scientific evidence, the available information continues to support the safety of BPA for the currently approved uses in food containers and packaging. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Learn how outdoors and chemistry work together. BISPHENOL A DIGLYCIDYL ETHER RESIN,25068-38-6 - Buyers Guide for Chemicals is a directory of chemicals, chemical suppliers and producers. Bisphenol A was first synthesized by A.P. This allows exposure to be easily determined by urine testing, facilitating convenient biomonitoring of populations. To fix the amount of fixed bisphenol A and make excess epichlorohydrin can obtain DGEBA. When the low-molecular-weight bisphenol A epoxy resin is continuously reacted with bisphenol A, the obtained bisphenol A epoxy resin has a high polymerization with a relative molecular mass 1400 or more. They are produced by the addition of - unsaturated carboxylic acids to epoxy resins. Although it is 1000- to 2000-fold less potent than estradiol, the major female sex hormone in humans. we live in today. Some, but not all, plastics that are marked with recycle codes 3 or 7 may be made with BPA. bisphenol A type Epoxy resin depending on the molecular weight and degree of polymerization n, the resin is yellow to amber transparent viscous liquid (or solid), the average molecular weight in the production of 300~700, n; 2, softening point below 50 is called low molecular weight epoxy resin (I. E. Soft resin); Molecular weight above 1000, n>2, those having a softening point above 60 C. From durable sneakers to waterproof jackets, chemistry plays a big role in all types of outdoor activities. Bisphenol A (BPA), a colourless crystalline solid belonging to the family of organic compounds; its molecular formula is C 15 H 16 O 2.BPA is best known for its use in the manufacture of polycarbonate plastics and epoxy resins, particularly those found in water bottles, baby bottles, and other beverage and food containers. Dont microwave polycarbonate plastic food containers. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. Strong, shatter-resistant polycarbonate is used for helmets and protective sports visors to help protectchildren and athletes from injuries. On the regulatory front, FDAs regulations authorize FDA to amend its food additive regulations to reflect when certain uses of an additive have been abandoned. Found that primates (including humans) of all ages effectively metabolize and excrete BPA much more rapidly and efficiently than rodents. Industrially, a large excess of phenol is used to ensure full condensation; the product mixture of the cumene process (acetone and phenol) may also be used as starting material. 133 Cecil Street, 80-05-7 Bisphenol a with Wholesale Price Min. Epoxy resins are made by reacting epichlorohydrin (ECH) and bisphenol A to produce a different chemical substance called bisphenol A diglycidyl ether (also known as BADGE or DGEBA). [11] www.who.int/foodsafety/areas_work/chemical-risks/bisphenol/en/, An official website of the United States government, : . [95] BPA in sediment degrades most slowly of all, particularly where this is anaerobic. What chemicals are in epoxy resin when you consider this? This petition demonstrated, from publicly available information and information collected from industry sources, that the use of BPA-based epoxy resins as coatings in packaging for infant formula had been abandoned. [2][7] BPA is produced on an industrial scale by the condensation of phenol and acetone, and has a global production scale which is expected to reach 10 million tonnes in 2022.[8]. - Buyers Guide for chemicals is a structural component in polycarbonate plastic and epoxy resins an..., risk, hazard and behaves as a constitutive activator of transcription the search for synthetic estrogens ] Monograph! 26Apr13 1 and beverage cans ligand unknown ) behaves as a drug contact.... 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bisphenol a epoxy resin chemical formula